抄録
Spontaneously occurring proliferative lesions of the accessory sex gland of the male rat are infrequent, but atypical hyperplasia of the prostate which has a various incidence in many rat strains. In rodents, the ampullary glands were embedded to locate in the prostatic complex. Although spontaneous atypical hyperplastic lesions of the ampullary gland were observed, the adenoma and adenocarcinoma of this gland have not been described. The present study described atypical hyperplasias, adenomas and adenocarcinomas in bilateral ampullary glands in 52-week-old intact male Sprague-Dawley rat housed as part of a control group in toxicological experiments. At necropsy, the prostate was normal-seeming and showed similar body weight to same group rats. A gross recognized prostate was measured weight 2.75 g. Histopathologically, the most frequent changes were observed in epithelial sites as prostatic intraepithelial neoplasias, adenomas, and microinvasive adenocarciomas, but vascular invasion was not observed. Other part of prostatic complex including sminal visicle and coagulating gland did not revealed proliferative lesions.
