Adverse Drug Reactions in Daegu Catholic University Medical Center, South Korea

抄録

As the voluntarily reporting Adverse Drug Reaction (ADR) by Electronic Medical Record (EMR) it is possible to manage the history of ADR from individual patients, and be able to contribute to patient safety. Therefore, the ADR monitoring team at Daegu Catholic University Medical Center has been studying ADR collected through EMR.

From JAN 2014 to DEC 2017 voluntarily reported ADRs are 796 Cases. The prevalence of ADR was as follow: non-narcotic analgesics (33.2%), antibiotics (27%), contrast medium (20.1%), narcotics (9.5%), circulatory drugs (2.6%), anti-cancer drugs (1.4%), digestive drugs (1.4%). The most common symptom was skin reaction (39.4%), followed by nausea/vomiting (38.4%), nervous symptom (8.9%), circulatory symptom (3.5%), respiratory symptom (3.1%). 13 cases were reported as serious adverse reaction such as anaphylaxis (1.6%). According to The World Health Organization-Uppsala Monitoring Center (WHO-UMC) causality criteria, 258 cases (32.4%) were 'Certain', 507 cases (63.7%) were 'Probable'. 19 cases (2.4%) were 'Possible' and 8 cases (1%) were 'Unrelated'.

Based on this study, non-narcotic analgesics and antibiotics were the most common causative drugs, and the most common clinical features were skin reaction and gastrointestinal symptoms. However, since there is a limit to the single center study, it is necessary to look at trends in multi-center studies or long-term studies in the future.