Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test of 3-methylpentane, isooctane, and isononane in rats

Abstract

Combined oral repeated-dose and reproduction/developmental toxicity screening tests were conducted in SD rats for 3-methylpentane, isooctane, and isononane, whose toxicological information was not available for human health effects. As the results, effects on the liver (weight increase, hypertrophy) and male kidney (α2u-globulin nephropathy, tubular regeneration), and no notable reproductive/developmental toxicity were observed in all compounds. This information will be useful to fill in the data gaps when evaluating other acyclic branched saturated hydrocarbons lacking toxicity information.