IEICE Transactions on Information and Systems
Online ISSN : 1745-1361
Print ISSN : 0916-8532
Special Section on Foundations of Computer Science
Inferring Pedigree Graphs from Genetic Distances
Takeyuki TAMURAHiro ITO
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2008 Volume E91.D Issue 2 Pages 162-169

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Abstract
In this paper, we study a problem of inferring blood relationships which satisfy a given matrix of genetic distances between all pairs of n nodes. Blood relationships are represented by our proposed graph class, which is called a pedigree graph. A pedigree graph is a directed acyclic graph in which the maximum indegree is at most two. We show that the number of pedigree graphs which satisfy the condition of given genetic distances may be exponential, but they can be represented by one directed acyclic graph with n nodes. Moreover, an O(n3) time algorithm which solves the problem is also given. Although phylogenetic trees and phylogenetic networks are similar data structures to pedigree graphs, it seems that inferring methods for phylogenetic trees and networks cannot be applied to infer pedigree graphs since nodes of phylogenetic trees and networks represent species whereas nodes of pedigree graphs represent individuals. We also show an O(n2) time algorithm which detects a contradiction between a given pedigreee graph and distance matrix of genetic distances.
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© 2008 The Institute of Electronics, Information and Communication Engineers
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