Abstract
The administration of glutamylcholine together with cholesterol in the rabbit suppresses the occurrence of hypertension and arteriosclerosis. The administration of glutamylcholine in the hypertension, experimentally induced in the rabbit by administration of cholesterol, resulted in a lowering of the blood pressure. No therapeutic effect could, however, be seen on the arteriosclerosis which had already set in, but a decrease in the fat deposition in various organs and small vessels was observed. The administration of cholestrol alone resulted in a picture of marked dysfunction of the adrenal cortex and decrease in function of the gonads. On the other hand, the changes in the adrenal cortex were milder and the gonads showed a grossly normal picture when glutamylcholine was given concomitantly. It is suggested from these facts that the action of glutamylcholine on blood pressure may be related to the metabolism of fat and to the endocrine system.
