STUDIES ON MECHANISM OF THIAMINE ABSORPTION : (III) EFFECT OF S-ALKYLMERCAPTOCYSTEINE AND ALKYLDISULFIDE ON THE INTESTINAL ABSORPTION OF THIAMINE

Abstract

Oral administration of TAD or TPD increased the thiamine excretion in the urine more than oral administration of thiamine did. Intravenous administration of S-allyl-mercaptocysteine, S-propylmercaptocysteine, allyldisulfide or propyldisufide did not increase the thiamine excretion in the urine. Oral administration of any of these substances did not increase the urinary thiamine excretion. Intravenous administration of any of these substances combined with oral administration of thiamine did not increase the thiamine excretion in the urine above the level found in a single oral administraion of thiamine. When either of these substances was given orally together with thiamine, the urinary thiamine discharge became larger compared with that at a single oral administration of thiamine. The magnitude of increase was simiar to that when TAD or TPD was administered orally.