1957 Volume 12 Pages 395-401
Diphosphopyridinenucleotide (DPN), and also adenosine used as a contrast, had a stimulating action on the uterus and bladder, and a relaxing effect on the intestines. The stimulating action of DPN on the uterus was decreased by papaverine. All the above actions were abclished by the use of atropine and pyribenzamine. Therefore, it would be justifiable to consider that DPN does not act on nervous centers, but acts on the periphery. Dilatations of blood vessels, congestions and localized bleedings were found in histological specimens when an over-dose of DPN had been given.
