THE EFFECTS OF X RAY IRRADIATION ON THE RIBOFLAVIN METABOLISM : (IV) THE INFLUENCE OF RIBOFLAVIN LOADING ON THE CHANGE OF RIBOFLAVIN DISTRIBUTION IN VARIOUS TISSUES OF THE IRRADIATED RAT

Abstract

Observations were made on post irradiated change of riboflavin contents in various tissues of the adult rats which were injected subcutaneously with 0.3μg of riboflavin per gram of body weight everyday before, or before and after, 800r irradiation. 1) The change of riboflavin contents in tissues of the irradiated rats loaded with the vitamin before irradiation were similar as the change of non-loaded rats, but the degree of change was more slight. 2) In the irradiated rats loaded with the vitamin before and after irradiation, free riboflavin was collected in tissues sensitive to X rays and excreted in urine. 3) From the above results, it may be considered that the post irradiate dchange of riboflavin contents are prevented slightly by loading the vitamin before irradiation, and that the esterification and consumption of riboflavin administered after irradiation are disturbed in tissues sensitive to X rays.