Abstract
Experiments were made on about 100 each of normal subjects and tuberculosis patients to see if there are any relations between the metabolism of thiamine, the metabolism of pyruvic acid and the liver function. 1) There was correlation between thiamine deficiency and disturbances in liver function and a more closer interrelation between thiamine deficiency and disturbances in metabolic function. 2) Sawada's urinary test was found to be interdependent upon disturbances in liver function and vagotonia. 3) In the group of subjects with liver function disturbances or vagotonia, there was a marked correlation between the results of Sawada's urinary test and those of thiamine administration test. 4) The cases showing an increased urinary excretion of pyruvic acid were all positive for Sawada's urinary test. 5) Changes in total protein and gamma globulin levels were most closely related to thiamine deficiency. 6) The group with positive Takada's test showed a rise in gamma globulin level, while the group with thiamine deficiency showed a fall in gamma globulin level.
