Abstract
Abderhalden observed that the toxicity of 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP) was greater in the mice fed DK diet than in those reared on the ordinary diet. The author examined the toxicity of OMP in pyridoxine deficient mice. When fed on synthetic pyridoxine-deficient diet for 5 days, the dose of OMP causing the death of 50 per cent animals fell to about 1/3.5 of that in normal animals, and the dose was smaller than that in the case with Dk diet.The time required for appearance of fatal convulsion by OMP was shorter in pyridoxine-dificient animals than in those with the ordinary or DK diet.
