Abstract
The action of an agent belonging to the atoxopyrimidine group, 2-methyl-4-amino-5-amino-methylpyrimidine, on the enzyme system of the brain related to the occurrence of the running fit, (glutamic decarboxylase, γ-aminobutyric-α-ketoglutaric transaminase and pyridoxal-kinase) was studied. It was found that all of these enzymes are inhibited and the inhibition of the former two is restored by pyridoxal-phosphate. Inhibition of the former two is intensified by preincubation but in this case, recovery was observed only with γ-aminobutyric-α-ketoglutaric transaminase.
