Abstract
In an attempt to clarify the running fit from the standpoint of brain metabolism, the enzyme system involved in the metabolic pathway from glutamic acid to γ-aminobutyric acid and then to succinic semialdehyde in the brain was studied. For inducing the running fit, 2-methyl-4-amino-5-hydroxymethylpyrimidine and thiosemicarbazide were used and pyridoxine and 2-methyl-4-amino-5-aminomethylpyrimidine were used for the suppression. It was found that at the time of the running fit, glutamic-decarboxylase was inhibited whereas when the seizure was suppressed, there is no inhibition. There was no inhibition of the γ-aminobutyric-α-ketoglutaric-transaminase. The findings suggest that γ-aminobutyric acid is decreased during the running fit.
