PHARMACOLOGICAL STUDIES ON OXYMETHYLPYRIMIDINE : (V) EFFECT OF CENTRAL NERVOUS SYSTEM DEPRESSANT ON THE CONVULSIONS INDUCED BY OMP, INAH OR THIAMINE

Abstract

The OMP convulsion and the death was completely antagonized by the administration of a proper dose of chloral hydrate and sodium diethylbarbiturate. Ether and urethan controlled the convulsion, but most of the treated mice died. Magnesium sulfate, potassium bromide, nicotinamide and pantothenic acid had little antagonistic effect. γ-Aminobutyric acid in the brain was decreased with OMP, and this decrease was not recovered by chloral hydrate treatment. The INAH and thiamine convulsion was depressed by a proper dose of sodium diethylbarbiturate. Ether and magnesium sulfate controlled INAH convulsion but the animal died. Potassium bromide had no influence on INAH convulsion.