Abstract
Chronic toxicity of thiamine tetrahydrofurfuryl disulfide (TTFD) in rats for 6 months has been studied. Rats were fed on the basal diet, to which 0,40,200,or 1,000 ppm of TTFD or thiamine hydrochloride was added. Even at the highest level of TTFD or thiamine hydrochloride, the body weight increase, food intake, food efficiency and organ weight of the rats have not been affected. Any anatomical and histological changes have not been checked. It was concluded that the chronic toxicity of TTFD in rats at a dose of over 2,500 times of usual human dosage in relation to body weight had been neglisible.
