Abstract
Thirty Wister strain male rats were divided into 3 groups and were kept for more than 90 days on natural diet, pyridoxine deficient casein diet, and 5μg/g of pyridoxine hydrochloride added diet. The growth curve, blood sugar, including the case of glucose toleranse test and insulin-glucose toleranse test, and the amount of 24 hours' urinary excretion of xanthurenic acid were compared. It was found that in spite of that the excretion of xanthurenic acid was not enough to cause hyperglycemia in normal rats, a continuous hyperglycemia still occurred in pyridoxine deficient rats distinctly as compared with controls after 35 days. An abnormal sugar metabolism in pyridoxine deficient rats was also confirmed. After 100 days, rats were minced and xanthurenic acid was estimated. The average amount of it in pyridoxine deficient rats was not more than 0.5mg per rat, which might be too low to cause the hyperglycemia. Hyperglycemia in pyridoxine deficient rat might not be caused by the accumulation of xanthurenic acid.
