Abstract
The growth of St.faecalis R was inhibited by low concentration of erythromycin. The inhibitory concentration was approximately 20〜200 mμg/ml. The extent of inhibition was decreased competitively as the Ca-pantothenate was increased. The growth of L.arabinosus 17-5 was inhibited by 100mμg/ml of erythromycin. But this inhibitory effect was not reversed by Ca-pantothenate. Inhibitory effect of erythromycin to erythromycin resistant strain of St.faecalis R, was also observed. It was suggested that erythromycin inhibits the utilization of Ca-pantothenate, but the mechanism is not single one as an antimetabolite.
