Abstract
During the last few years we have been studying the pharmacological and therapeutic effects of pyridoxal phosphate. In this paper the author examined its effect in the treatment of patients with hyperthyroidism. Moreover, the function of pyridoxal phosphate upon hyperthyroidism was studied. Twenty-nine cases of hyperthyroidism were treated with pyridoxal phosphate. In 15 cases the toxic manifestation was improved satisfactorily and the basal metabolic rate returned to a normal range. Blood-iodine, examined on 5 patients, showed in 4 cases a fall of the protein-bound iodine to a normal level. In experimental studies, pyridoxal phosphate inhibited decarboxylase and tryptophanase of Escherichia cold and oxygen consumption of the tissues of rats. The synthesis of organic iodine compounds by surviving slice of thyroid tissue was inhibited by pyridoxal phosphate.
