Abstract
Researches have been done for testing the function of adrenal cortex with vitamin B_6 deficient rats. The corticoid content of blood was determined by Sweet-Takeda's method and the adrenal tissue was examined histochemically. It was shown that the adrenal function was lowered by the vitamin B_6 deficiency and the more the dificiency pronounced, the more the degeneration of adrenal cortex was remarkable. It is already known that the pituitary-adrenal cortex system is controlled by the central nervous system, but in the author's experiments, it was confirmed that the supply of ACTH was able to restore the drawback of pituitary, but not the failure of adrenal cortex. Thus the author supposed that the failure of adrenal function was partly due to the defect in peripheral production of cortex hormone.
