Abstract
The effects of injection of cocarboxylase or adenosinetriphosphate upon the myocardial metabolism in experimental coronary insufficiency were studied on 55 dogs. (1) The use by myocardia of pyruvate, lactate, α-ketoglutaric acid, inorganic phosphate, potassium and magnesium decreased gradually after thoracotomy. (2) The metabolic change due to the experimental coronary insufficiency was more significant, so that the myocardial use of these compounds markedly decreased or became negative. (3) After the injection of cocarboxylase or adenosinetriphosphate the myocardial use of these compounds increased for some time. From the above results, it seems true that cocarboxylase and adenosinetriphosphate are able to restore the disturbances in myocardial metabolism induced by myocardial hypoxia.
