Abstract
In order to study on the effects of antibiotics upon the riboflavin metabolism, the change of riboflavin level in blood caused by the administration of antibiotics was observed in patients of liver and kidney deseases and in normal subjects. A significant decrease of the amount of total and esterified riboflavin and the ester ratio in blood was observed in the patients. In all cases, a temporary decrease of riboflavin content of blood occurred by the administration of antibiotics. The effect of antibiotics was more remarkable on patients than on normal subjects. Even if antibiotics was administered, clinical signs of riboflavin deficiency were scarcely detected. However, there may be some conditions, being susceptible to the deficiency in the patients.
