Abstract
The rate of increase of pyruvate and α-ketoglutarate in urine excreted for the first one hour and the next one hour after an intravenous administration of 20ml of 20% fructose solution was higher in patients of liver disease, diabetes mellitus and polyneuritis than in the normal subjects. The acetylating activity after an oral administration of 500 mg p-aminobenzoic acid was lower in these patients than in the normal subjects. An administration of 10 mg α-lipoic acid improved the distubance of the α-keto acid metabolism and acetylation in these patients.
