Abstract
Studies were made, using rats, on the urinary excretion of α-lipoic acid and its content of the liver in such conditions as acute or chronic CCl_4 poisoning, alloxan diabetes and thiamine deficiency. Chronic CCl_4 poisoning and thiamine deficiency caused a remarkable decrease of the urinary excretion of α-lipoic acid, while in alloxan diabetes the excretion rather increased. The hepatic content of α-lipoic acid in rats in all experimental conditions was lower than that in the normal rats. However, the decrease of the hepatic content caused by acute CCl_4,poisoning was not so much remarkable.
