Abstract
The daily intraperitoneal injection of 10μg thiamine sulfuric acide ster (I) or 14μg thiamine benzenesulfonate (II) to albino rats on thiamine-deficient diet failed to promote their growth. Later daily dosage was increased to 1OOμg and yet the rats lost their weights. 100μg of II, given orally, however, resulted in a prompt response of weight-gain which suggested hydrolysis of II into thiamine in intestinal tracts. Daily injection of 200μg (I) showed still loss of weight, then an additional daily dosage of 10μg thiamine gave the same response curve as that of thiamine alone. Thus I has been proved to have no anti-thiamine activity to rats.
