STUDIES ON THE PYRUVATE- AND XANTHINE OXIDASES IN RATS, ADMINISTERED WITH ANTIBIOTICS : (II) CHANGES ON METABOLISM OF THIAMINE AND RIBOFLAVIN IN LIVER BY THE ADMINISTRATION OF A SMALL QUANTITY OF AUREOMYCIN

Abstract

On administration of Aureomycin in a small quantity to rats, the thiamine content in liver changed in parallel with the pyruvate oxidase, showing higher values compared with those of the control animals. Riboflavin, FAD and xanthine oxidase increased in the early stage and then decreased in parallel. The proportion of FAD was unchanged even when Aureomycin was administered for a long time. In vitro, addition of Aureomycin in liver homogenate had no influence on the pyruvate- and xanthine oxidases.