STUDIES ON THE PYRUVATE- AND XANTHINE OXIDASES IN RATS, ADMINISTERED WITH ANTIBIOTICS : (III) CHANGES IN METABOLISM OF THIAMINE AND RIBOFLAVIN, PYRUVATE- AND XANTHINE OXIDASES IN LIVER BY THE ADMINISTRATION OF A LARGE QUANTITY OF ACHROMYCIN

Abstract

In rats administered with a large quantity of Achromycin, the thiamine content and the pyruvate oxidase of liver decreased in the early stage and, after a transitory recovery, they fell again. The contents of riboflavin and FAD and xanthine oxidase decreased and the latter two changed parallel with each other. The effect of a large quantity of Achromycin on the liver vitamins and the concerning enzymatic activities were smiller to those of Aureomycin.