Abstract
It has been already demonstrated that the synthesis of organic iodine compounds by surviving slice of thyroid tissue of the rat was inhibited by pyridoxal phosphats, pyridoxal, pyridoxine phosphate and pyridoxamine. In this paper the effect of pyridoxal phosphate, pyridoxal and pyridoxamine phosphate for the synthesis of thyroid hormones in the rat in vivo, respectively was examined. It resulted that pyridoxal phoshate, pyridoxal and pyridoxamine phosphate did not influnce on the synthesis of monoiodotyrosine and diiodotyrosine, but that pyridoxal phosphate inhibited the biosynthesis of thyroxine. Pyridoxal and pyridoxamine phosphate did not inhibit it.
