Abstract
Histopathological studies were made on the changes in the reproductive and endocrine organs of rats, fed on a vitamin E deficient diet. Marked degeneration and atrophy were observed in the testis. These changes were considered to be produced by the inhibition of spermatogenesis following the necrosis of spermatogonia. Electronmicroscopic studies revealed that the degeneration and necrosis of spermatogonia were caused by the degeneration and destruction of the mitochondria and endoplasmic reticulum of the testis. A remarkable proliferation of interstitial cells occurred with the degeneration and atrophy of the seinal tubes. From the electronmicroscopic pattern, it was concluded the endoplasmic reticulum concerns the granule formation in the interstitial cells. Changes of the hypophysis and adrenal systems were also investigated and the significance of the systems in vitamin E deficiency was discussed.
