In order to study the effect of thiamine upon the zinc metabolism, the change of zinc excretion in urine caused by the administration of thiamine or thiamine propyldisulfide was observed in man. When 10 mg of thiamine propyldisulfide was administered intravenously or orally, the urinary excretion of zinc decreased remarkably. But the effect of an intravenous administration of 10 mg thiamine was not remarkable.
