Abstract
Histopathological studies were performed on the digestive organs of experimentally produced vitamin E deficient rats. Atrophy of glandular cells was found in stomach, and desquamation of epithelial cells and inflammatory cell infiltration of submucosa were observed in bowel. Fatty degeneration and necrosis of liver cells were found in the central area of lobules. This may be produced by vitamin E deficiency only, and does not necessitate a lack of sulfur-containing amino acids. In the pancreas, necrosis of pancreatic cells was found, suggesting a possibility to fibrosis. The-vitamin E deficiency is considerd as one of the causative fators for human pancreatic necrosis.
