Abstract
Intravenous injection of thiamine propyldisulfide (TPD) produces an excitatory effect on the movements of the small intestine in the dog, while thiamine preparations of the other manufacturers exert no effect. When TPD is applied to the exposed mucosa. of the small intestine, the intestinal movements above the spot applied are remarkably excited, while the other thiamine preparations has no effect on them. When 0.033 or 0.05% of TPD solution is perfused through the intestinal loop at a given pressure, the weak movements of the intestinal loop are activated and the outflow volume of fluid through the intestinal loop is enhanced. On the other hand ; when the intestinal movements are under an active condition they are accelerated, but because of increase of the muscular tone the lumen becomes narrow, with a consequent decrease in the outflow volume of fluid through the intestinal loop.
