Abstract
The parenteral use of orotic acid in male albino rats causes fatty infiltration in the tubules, particularly in the convoluted tubules of the cortex of the kidney and peripheral parts of the lobules in the liver. The minimal dose of orotic acid producing the fatty change is 5mg/100g in a single injection and 0.2-0.04mg/100g in the repeated injections. The accumulation of fat in the kidney and the liver was also induced by the oral administration of orotic acid more than 10 mg for 15 days. An injection of orotic acid does not exert the beneficial effect on the experimental liver damage by carbon tetrachloride in rats.
