STUDY ON THE STABLE SALTS OF THIAMINE

Abstract

It is well known that thiamine hydrochloride is unstable in the presence of calcium carbonate or ascorbic acid. The authors synthesized three kinds of stable salt of thiamine, namely thiamine di-diphenyl monosulfonate, dithiamine diphenyl-4,4'-disulfonate and thiamine diphenyldisulfonate. They are difficult soluble in water, tasteless, odorless, non-toxic and stable even in the presence of calcium carbonate. Dithiamine diphenyl-4,4'-disulfonate is easily absorbed from digestive tract and blood thiamine concentration is maintained higher level for a long time than thiamine hydrochloride, so that the salt may be well used for the treatment of latent beriberi.