HISTOPATHOLOGICAL STUDY ON THE LESION OF THE RATS IN HYPERVITAMINOSIS A

Abstract

The lesion of each organ of the rats administrated with 50,000 I.U. of vitamin A-acetate for 7-15 days was examined histologically. After describing the pathological changes of heart, liver, kidneys, brain, peripheral nerve fibers and end-plates in skeletal muscle, bone, endcrine glands etc., the author discussed the effect of synthetic vitamin A on the living bodies comparing with the old examination using liver oil. From the histological finding of thalamo-hypophyseal system, it was pointed out that the hypervitaminosis was regarded as a kind of stressor.