STUDIES ON THIAMINE PHOSPHATES : (I) BIOLOGICAL PROPERTIES OF S-BENZOYLTHIAMINE O-MONOPHOSPHATE

Abstract

In the course of studies on thiamine phosphates we found that a new derivative of thiamine monophosphate, S-benzoyl-thiamine O-monophosphate (BTMP) is easily absorbed into organisms. BTMP exerts thiamine activity approximately equivalent to that of thiamine hydrochloride in a thiamine requiring organism, Lactobacillus fermenti 36,rice bird and pigeon. BTMP is hardly decomposed by thiaminases produced by Bacillus thiaminolyticus and Bacillus aneurinolyticus. BTMP is readily absorbed in the human body as well as in dog or mouse, by oral administration and consequently the blood thiamine levels, the thiamine contents of organs and blood cocarboxylase activity rise remarkably and the risen levels last for a long time. Subcutaneously and intravenously administered BTMP causes higher blood thiamine level and cocarboxylase activity than thiamine hydrochloride.