Abstract
The effect of α-tocopherol phosphate on blood coagulation was investigated systematically in vitro. Changes by the addition of α-tocopherol phosphate of recalcified plasma clotting time, thromboplastin generation test, prothrombin time, thrombin time and fibrinolysis were observed. Recalcified plasma clotting time, prothrombin time and thrombin time were prolonged with increase of α-tocopherol phosphate concentration. Generation time of thromboplastin was delayed and its production decreased. Lysis time of fibrin clot was reduced. These results indicate that α-tocopherol phosphate acts as anticoagulant in the first and the third phase of blood coagulation, while activating fibrinolysis
