Abstract
The biological utilization of some thiamine derivatives was investigated by estimating the formation rate of cocarboxylase from the derivatives by rat liver supernatant. The time course of cocarboxylase formation was determined manometrically by using apocarboxylase extracted from bakers' yeast. Thiamine was most predominant, thiamine propyldisulfide and S-benzoylthiamine monophosphate was a little delayed in the cocarboxylase formation while thiamine-thioctate disulfide was almost same as thiamine and the formation rate from O-benzoylthiamine disulfide was smaller than the other thiamine derivatives.
