Abstract
Six healthy adults and children were performed with oral administration of a new thiamine decomposing bacillus. All subjects were proved to be afficted with thiaminase disease and it was worthy of noted that 3 adults of them complained remarkable gastrointestinal disturbances and beriberi-llike disorders. On the other hand, in those adults administered with B. thiaminolyticus, thiaminase and decrease of amounts of thiamine in feces took place temporally, but no marked complaints occured, and thiaminase disease could not be proved in experiments by intake with B. aneurinolyticus. According to the results of immunological investigations, reactions of agglutination and precipitation with thiamine decomposing bacilli in human blood serum can be utlized to detect thiaminase disease.
