Abstract
TPD or thiamine whose sulfur in thiazole part was labelled, was administered to rat, orally or intravenously and the TPD or thiamine content of various organs was compared. The results revealed that TPD was distributed in the organs in larger amounts than thiamine. The radioactivity in the organs after an oral administration of labelled TPD was assumed to represent thiamine, except for the thiamine decomposed in the tissue. There was a difference in the amounts of radioactivity in the organs between rats fed on a normal and thaimine deficient diets. Radioactivity was not detected after I week in the former, while in the brain, skin, testes and muscles of the latter, it was found as much radioactivitay 1 week later as 2 hours later.
