Abstract
The authors studied on the effect of lipoic acid and lipoic acid derivatives, such as lipoamide, dihydrolipoic acid, e-N-lipoyl-L-lysine, thiamine-8-(methyl-6-acetyl-dihydrothioctate) disulfide, on the experimental liver damage by CCl_4 in rats, and it was observed that lipoic acid and its derivatives alleviated the liver lesion by CCl_4. The alleviation of the liver lesion by lipoyl-L-lysine was milder than that by the other derivatives. It is conceivable that the alleviation of the liver lesion by lipoic acid derivatives is derived from lipoic acid.
