By morphological and histological examinations of the internal organs of albino rat, administered with p-phenylenediamine, atrophy and degeneration of liver cells, congestion of kidney, gastritis and dermatitis were recognized. Occationally, a slight skin disorder was seen by a single application of p-phenylenediamine, but the changes of the internal organs, accompanied by the loss of weight and decrease or urine, appeared in prolonged administration.
