Abstract
The phosphorylating and dephosphorylating activities of thiamine in the rat liver with carbon tetrachloride poisoning were discussed. The phosphorylating activity increased slightly in the supernatant and the mitochondria, but the activity did not change in the nuclei. The dephosphorylating activity of esterfied thiamine increased in the supernatant, mitochondria and administnuclei. These results suggest that the decrease of thiamine content of the rat liver by the ration of carbon tetrachloride is owing to an increasing dephosphorylation rather than a decreasing phosphorylation.
