Abstract
Decline in growth in male Wistar rats receiving a synthetic thiamine-deficient diet was effectively protected by the daily administration of TATD in dosage equivalent to 5 or 100μg of thiamine hydrochloride per animal as has been observed in similar administration of thiamine. Growth promoting activity of TATD in Streptococcus faecalis 10C1 was approximately equivalent to that of lipoic acid on the basis of a mole. However, since it was observed that disulfide linkage of TATD was split to liberate thiamine under the condition of heat sterilization or incubation in a culture medium, the response of bacterial cells may not be to TATD molecule but to lipoate derivative released from TATD.
