Abstract
0.5% of thiamine terahydrofurfuryldisulfide (TTFD) is applied to the mucosa of jejunum of anesthetized dogs from which the metenseric nerves has been cut, an intra-mucousal reflex occurs, and the peristalsis of the oral side to the point of application increases while that of the caudal side is suppressed. When 1.5mg to 5 mg/kg of TTFD is injected intravenously, a marked increase in the peristalsis of the small bowel occurs 2 to 3.5 minutes later. Since there is a relatively long time lapse before this stimulative effect is seen, it is felt that this effect is due to an intermediate compound which is formed when TTFD is changed to thiamine.
