Abstract
A general method for the synthesis of pyridoxal adenosine diphosphate and related compounds is described. It consists of the reaction of adenosine-5-phosphoromorpholidate with pyridoxal-5-phosphate, pyridoxamine-5-phosphate and pyridoxine-5-phosphate in anhydrous pyridine or dimethylformamide. The method has been applied to the preparation of pyridoxal-, pyridoxamine- and pyridoxine adenosine diphosphate. The yields of nucleotides were generally satisfactory, varying between 40 and 52%.
