Abstract
The reaction of inosine-5-phosphoromorpholidate with pyridoxal-5-phosphate in anhydrous pyridine gave pyridoxal inosine diphosphate in 35% yield, after 15 hours at 40-50℃. Similarly, it was synthesized from pyridoxal adenosine diphosphate by deaminization with nitrous acid in 40% yield. Irradiation of alkaline solution of pyridoxal inosine diphosphate under aerobic condition yielded mainly pyridoxic acid inosine dinucleotide. The latter was obtained by the reaction of inosine-5-phosphoromorpholidate with 4-pyridoxic acid-5-phosphate in 28% yield.
