STUDIES ON THE HYPOPHYSIC REGULATION OF TRANSAMINASE ACTIVITIES IN LIVER AND BRAIN FROM THE VIEWPOINT OF RELATION TO VITAMIN B_6 METABOLISM : (III) EFFECT OF VITAMIN B_6 ON GOT ACTIVITIES OF LIVER AND BRAIN IN HYPOPHYSECTOMIZED RATS

Abstract

It was noticed that the addition of pyridoxal phosphate to liver homogenate of hypophysectomized rat was effective to recover the decreased GOT activities almost completely among 15 days after the operation. After the limited period (approximately 15 days) this effect of pyridoxal phosphate was seldom recognized. Oral administration of pyridoxine to hypophysectomized rat was effective for the recovery of the enzyme activities of liver, too, but the effect was weaker than that of the pyridoxal phosphate described above.