STUDIES ON THE HYPOPHYSIC REGULATION OF TRANSAMINASE ACTIVITIES IN LIVER AND BRAIN FROM THE VIEWPOINT OF RELATION TO VITAMIN B_6 METABOLISM : (IV) EFFECT OF ACTH ADMINISTRATION ON GOT ACTIVITIES OF LIVER AND BRAIN IN HYPOPHYSECTOMIZED RATS

Abstract

Hepatic GOT activities of normal rat increased slightly as a result of successive intramuscular injections of ACTH (1 unit per day). Effect of ACTH injections on GOT activities of liver in hypophysectomized rat was more remarkable than that of addition of pyridoxal phosphate in vitro or pyridoxine administration in vivo, described previously. It was concluded from the authors' results that hepatic GOT activities was controlled by hypophysic-adrenal system and discussed on this regulation mechanism from the viewpoint of relation to vitamin B_6 metabolism in these reports. In addition, it was noticed that the attitude of GOT of brain in hypophysectomized rat was quite different from that of liver. This result is likely due to the difference of relation between pyridoxal phosphate and apo-GOT molecule, tissue to tissue.