Abstract
The estimation of vibratory perception using biothesiometer has been often used for the diagnosis of diabetic neuropathy as one of the useful objective criteria. This abnormality was more frequently observed in elderly people in diabetics and nondiabetics. Statistically significant difference between both groups in each same age was demonstrated in relation to such abnormality. Thiamine tetrahydrofurfuryl disulfide, which is a long acted derivative of thiamine, and riboflavin both were used for the treatment of neuropathy in normal and diabetics. The administration of these vitamins for 1 to 3 months produced an improvement in vibratory perception as well as patellar tendon reflex and subjective symptoms. The increasing ratio of urinary excretion of pyruvate and α-ketoglutarate following fructose loading was also decreased by such treatment in these patients.
