VITAMINS

EFFECT OF TOPICAL APPLICATION OF VITAMIN E ON RABBITS HAIR GROWTH

Mitsuo KAMIMURA, Naoko SASAKI

Article type: Article
1964 Volume 29 Issue 4 Pages 239-243
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_239

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Experimental studies of the topicaly applicated α-tocopherol on the rabbits hair growth were done. It was found that the α-tocopherol lotion accelerated the weekly hair growth and shortened the anagen time of hair growth. There was not so much difference on the action of α-tocopherol and α-tocopheryl acetate.

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INFLUENCE OF VITAMIN B_T ON GROWTH OF CHICKS : (II) ON THE AMOUNTS OF VITAMIN B_T AND CHOLINE FOR GROWTH OF CHICKS

Naomi TAKAHASHI, Yasushi MASHITA, Sota TAKAHASHI

Article type: Article
1964 Volume 29 Issue 4 Pages 244-248
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_244

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The diets added with the single or combined supplementation of 100mg of carnitine and 1-4 g of choline per kg were given for 2〜4 weeks to male White Leghorn chicks of seven days old, and the influences of these substances on the growth of chick were examined. The basal diet consisted of ground corn 47%, rice bran 10%, wheat bran 15%, soybean oil meal 15%, fish meal 10%, minerals, liver oil and vitamin B mixture, devoid of choline. During 2-4 weeks trials, the single supplementation of 100mg of carnitine or 1-4 g of choline, and the combined supplementation of 100mg of carnitine with 1-2 g of choline improved the growth of chicks and their body weight increased 9-20% over the control and the gain of the body weight in the trials given doses of 100mg of carnitine is almost the same as that of 4 g of choline. At the end of the trials, all chicks were killed and the compositions of liver were compared, and no difference was found among the chicks given these supplementation. The fatty liver was not found in any chick all through the trials. From these results the authors concluded that 100 mg of carnitine has the same effect for the growth of chicks as that of 4g of choline and the action of antivitamin did not occur in each other.

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THE EFFECT OF THIAMINE TETRAHYDROFURFURYL DISULFIDE ON VIBRATORY PERCEPTION OF PATIENTS WITH DIABETIC NEUROPATHY

Masahisa WADA, Yukio SHIGETA, Koji NAKAMURA, Motoaki SHICHIRI

Article type: Article
1964 Volume 29 Issue 4 Pages 249-254
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_249

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The estimation of vibratory perception using biothesiometer has been often used for the diagnosis of diabetic neuropathy as one of the useful objective criteria. This abnormality was more frequently observed in elderly people in diabetics and nondiabetics. Statistically significant difference between both groups in each same age was demonstrated in relation to such abnormality. Thiamine tetrahydrofurfuryl disulfide, which is a long acted derivative of thiamine, and riboflavin both were used for the treatment of neuropathy in normal and diabetics. The administration of these vitamins for 1 to 3 months produced an improvement in vibratory perception as well as patellar tendon reflex and subjective symptoms. The increasing ratio of urinary excretion of pyruvate and α-ketoglutarate following fructose loading was also decreased by such treatment in these patients.

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PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES : (II) COMPARISON OF THIAMINE PROPYLDISULFIDE AND DICARBETHOXYTHIAMINE

Chikataro KAWASAKI, Sumio SHINODA

Article type: Article
1964 Volume 29 Issue 4 Pages 255-259
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_255

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Thiamine propyl disulfide (TPD) or dicarbethoxythiamine (DCET) can penetrate into bovine erythrocytes either in whole blood or in suspension of erythrocytes in Krebs-Ringer phosphate buffer ; TPD, when added to a suspension of erythrocytes, was quickly and completely absorbed by the erythrocytes but DCET was only partly and gradually absorbed by them. When applied to whole blood, TPD was incompletely absorbed by erythrocytes, while DCET was absorbed by them to nearly the same percentage as in the case of a suspension. DCET in erythrocytes was washed out by repeated shaking with saline solutions, whereas no washing out of the erythrocytes which contained TPD, by saline was observed. DCET is rather stable either in erythrocytes or in serum ; slow reduction of DCET to thiamine was demonstrated by both paper partition chromatography and microbiologiaal assay using Kloeckera apiculata. TPD was quickly reduced to thiamine both by serum and by hemolyzed erythrocytes. The difference between TPD and DCET in their stability in blood systems is partly responsible for easy or slow penetration into erythrocytes.

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ON THE VITAMIN B_6-SYNTHESIZING BACTERIA

Yukio HARUNA

Article type: Article
1964 Volume 29 Issue 4 Pages 260-261
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_260

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A strain of the vitamin B_6-synthesizing bacteria, isolated from the soil by Suzue and Haruna, was found to retain its original vitamin B_6 synthesizing ability after 19 passage in agar medium. The vitamin B_6 synthesizing ability of a strain of Klebsiella pneumoniae, and that of Aerobacter aerogenes, to which our strain was thought to belong, were found to be 1/2 and 1/10,respectively compared with our strain.

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STUDIES ON THE α-LIPOIC ACID METABOLISM IN CHILDREN : (I) THE URINARY EXCRETION OF α-LIPOIC ACID IN CHILDREN

Kiyosaburo KONISHI

Article type: Article
1964 Volume 29 Issue 4 Pages 262-267
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_262

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The α-lipoic acid activity of urine was found to be increased in association with growth of normal children and the excretions rate to be 25〜45 mμg/2 hours per kg of body weight. The excretions of lipoic acid in nephrotic syndrome and in acute nephritis were low as compared with that of normal children, while in emaciations these excretion were rather high. After intravenous injection of α-lipoic acid 1mg/kg to normal children, the ratio of lipoic acid excretion in the first 2 hours was 0.2〜0.7 %. The ratios in children with nephrotic syndrome and nephritis were low and it increased after the improvement of their illness.

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STUDIES ON THE α-LIPOIC ACID METABOLISM IN CHILDREN : (II) EFFECT OF DIET COMPOSITION ON THE α-LIPOIC ACID METABOLISM IN WEANING AND MATURE RATS

Kiyosaburo KONISHI

Article type: Article
1964 Volume 29 Issue 4 Pages 268-274
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_268

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Studies were made on the urinary excretion of α-lipoic acid and its content of blood serum, kindney and liver tissue, using mature and weaning rats, fed on the low-protein diet (casein 5 %) and standard diet (casein 18%). In the low-protein fed mature rats, the α-lipoic acid levels were low as compared with the control. In weaning rats, the serum levels and hepatic contents decreased but renal contents were rather increased. The hepatic content of α-lipoic acid decreased most remarkably in weaning rats of protein deficiency. The α-lipoic acid contents in liver tissue were low in young rats fed on the trypthophan or lysine deficient diet. Those results suggest that appropriate intake of protein and well-balanced amino-acid in diet are required for the maintenance of normal metabolic process of α-lipoic acid.

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STUDIES ON THE α-LIPOIC ACID METABOLISM IN CHILDREN : (III) EFFECT OF DIETARY PROTEIN CONTENT AND ANABOLIC STEROID ON THE LIPOIC ACID METABOLISM IN YOUNG RATS

Kiyosaburo KONISHI

Article type: Article
1964 Volume 29 Issue 4 Pages 275-281
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_275

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The effect of anabolic steroid (19-norandrosterone phenylpropionate) on the lipoic acid metabolism was observed in young rats, fed on 5 % casein diet for 4 weeks (group 1,2), 5% casein for 2 weeks then 18 % casein for another 2 weeks (group 3,4), and 18 % casein for 4 weeks (group 5,6). The groups 2,4 and 6 were injected with 0.5 mg of the steroid in every 2 days for last 2 weeks. The effect of the steroid was most effective in group 4,which showed remarkably higher weight gain, serum protein, serum lipoic acid levels, hepatic contents of nitrogen and lipoic acid than the control group (group 3). By the steroid injection, the hepatic content of lipoic acid was not changed in low protein-diet group (group 2), but in 18 % casein diet group (group 6) rather decreased. Though the steroid caused an increase of the weight of kidney, while the content of liopic acid usually decreased.

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EFFECT OF STORAGE TEMPERATURE ON CAROTENE STABILITY IN A DEHYDRATED ALFALFA MEAL TO WHICH ETHOXYQUIN WAS ADDED

Tetsunosuke TAKASAKI

Article type: Article
1964 Volume 29 Issue 4 Pages 282-284
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_282

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To test the carotene stability in dehydrated alfalfa meal (pellated) which was treated with ethoxyquin (antioxidant) and stored under an inert gas until sent from the dehydrated feed manufactures Co., samples were divided into equal amount. One lot was stored at 2〜3℃, the othes were stored under room temperature during the storage test period. As shown in the tables, carotene retention was not similar in the storage samples. The results showed that the dehydrated meal stored at room temperature retained noly 49 per cent of the original carotene. But samples which stored at low temperature showed better retention of carotene. And the difference of carotene retention was about 12 percent at the end of the test period. The analytical data obtained for the dehydrated alfalfa meal samples show definite trends that may be related to storage temperature even though ethoxyquin was added. The data obtained in this study strongly suggest that the storage temperatures are important factor in the retention of carotene in dehydrated meal even when it is treated with the stabilizer, ethoxyquin.

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BIOASSAY OF LIPOIC ACID IN ANIMAL TISSUES

Shinichiro KAWASHIMA

Article type: Article
1964 Volume 29 Issue 4 Pages 285-288
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_285

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Lipoic acid content in animal tissues were estimated by the titration method using Streptococcus faecalis R, described previously. Lipoic acid values estimated in non-hydrolyzed samples showed practically no difference between animal species except mouse liver. The administration of lipoic acid, per os or intravenously, caused an increase of lipoic acid level in blood, however the high level continued for a short time (1〜2 hrs), then it reduced rapidly to a normal level. The determination of total lipoic acid in blood was investigated by autoclaving with H_2SO_4 or HCl and or in the presence of nitrogen gas. The hydrolysis in 6N H_2SO_4 solution was most adequate, however the recoveries of lipoic acid added to the sample gave always high value than the theoretical one. This means that the hydrolyzed blood sampes probably contain some activating factors for growth of the microbes.

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 289-290
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_289

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 290-291
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_290

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 291-292
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_291

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 292-293
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_292

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 293-295
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_293

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 295-296
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_295

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 296-297
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_296

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[title in Japanese]

[in Japanese], [in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 297-298
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_297

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[title in Japanese]

[in Japanese]

Article type: Article
1964 Volume 29 Issue 4 Pages 298-299
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_298

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THIN LAYER CHROMATOGRAPHY OF VITAMINS : (III) THIN LAYER CHROMATOGRAPHY OF WATER-SOLUBLE VITAMINS

Goichiro KATSUI

Article type: Article
1964 Volume 29 Issue 4 Pages 300-305
Published: April 25, 1964
Released on J-STAGE: February 01, 2018

DOIhttps://doi.org/10.20632/vso.29.4_300

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