Abstract
The α-lipoic acid activity of urine was found to be increased in association with growth of normal children and the excretions rate to be 25〜45 mμg/2 hours per kg of body weight. The excretions of lipoic acid in nephrotic syndrome and in acute nephritis were low as compared with that of normal children, while in emaciations these excretion were rather high. After intravenous injection of α-lipoic acid 1mg/kg to normal children, the ratio of lipoic acid excretion in the first 2 hours was 0.2〜0.7 %. The ratios in children with nephrotic syndrome and nephritis were low and it increased after the improvement of their illness.
